# modlib: PK/PD Model parameters, compartments, and output variables

Source:`R/modlib.R`

`modlib_details.Rd`

modlib: PK/PD Model parameters, compartments, and output variables

## Compartments

`EV1`

,`EV2`

: extravascular dosing compartments`CENT`

: central PK compartment`PERIPH`

: peripheral PK compartment`PERIPH2`

: peripheral PK compartment 2`RESP`

: response PD compartment (irm models)

## PK parameters

`KA1`

,`KA2`

: first order absorption rate constants from first and second extravascular compartment (1/time)`CL`

: clearance (volume/time)`VC`

: volume of distribution, central compartment (volume)`VP`

: volume of distribution, peripheral compartment (volume)`VP2`

: volume of distribution, peripheral compartment 2 (volume)`Q`

: intercompartmental clearance (volume/time)`Q2`

: intercompartmental clearance 2 (volume/time)`VMAX`

: maximum rate, nonlinear process (mass/time)`KM`

: Michaelis constant (mass/volume)`K10`

: elimination rate constant (1/time);`CL/VC`

`K12`

: rate constant for transfer to peripheral compartment from central (1/time);`Q/VC`

`K21`

: rate constant for transfer to central compartment from peripheral (1/time);`Q/VP`

## PD parameters

`E0`

: baseline effect (emax model)`EMAX`

,`IMAX`

: maximum effect (response)`EC50`

,`IC50`

: concentration producing 50 percent of effect (mass/volume)`KIN`

: zero-order response production rate (irm models) (response/time)`KOUT`

: first-order response elimination rate (irm models) (1/time)`n`

: sigmoidicity factor`KEO`

: rate constant for transfer to effect compartment (1/time)