library(mrgsolve)
library(dplyr)
<- house(end = 72, delta = 0.1) %>% update(outvars = "CP")
mod
<- param(mod, CL = 2)
mod
<- ev(amt = 0, rate = 100, ss = 1, cmt = 2) dose
1 Introduction
Starting with version 0.10.0 (released October, 2019), mrgsolve can implement dosing records calling for a zero-order infusion at steady state. To do this, set rate
to a non-zero value, amt
to zero, and ss
to 1.
2 Example
For a 10 mg/hr infusion at steady state
The dosing event looks like
dose
Events:
time amt rate cmt evid ss
1 0 0 100 2 1 1
With CL
set to 2, we expect the system to start out at 50
mrgsim(mod,dose,recsort = 3) %>% plot()
3 Notes
- It is an error to include addl
- You can model the rate
- Set
rate
to -1 in the input data - Set
R_CMT
in[main]
- Set
- It is an error to try to model the duration
- Set
rate
to -2 in the input data - Set
D_CMT
in[main]
- Set