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modlib: Pharmacokinetic / pharmacodynamic models

Source: R/modlib.R
modlib_pkpd.Rd

modlib: Pharmacokinetic / pharmacodynamic models

Details

See modlib_details for more detailed descriptions of parameters and compartments.

All PK/PD models include 2-compartment PK model with absorption from 2 extravascular compartments and linear + nonlinear clearance. The PK models are parameterized with CL, V2, Q, V3, VMAX, KM, KAandKA2and implement compartmentsEV, EV2, CENT, PERIPH. The indirect response models have compartment RESPand the emax model has output variableRESP. PD parameters include KIN, KOUT, IC50, EC50, IMAX, EMAX, E0, and n`.

Also, once the model is loaded, use the see() method for mrgmod to view the model code.

Model description

  • irm1: inhibition of response production

  • irm2: inhibition of response loss

  • irm3: stimulation of response production

  • irm4: stimulation of response loss

  • pd_effect: effect compartment model

  • emax: sigmoid emax model